![]() ![]() Therefore, representing this unique property of these cancers in mice is desirable in order to accurately model tumor-stroma interactions and glioma cell behavior. Gliomas do not display the well-circumscribed morphology typical of many other solid tumors. Recapitulation of the diffuse and infiltrative nature of glioma has been challenging to achieve in murine glioma models. As lower-grade gliomas invariably progress to secondary GBMs, evaluating the role of IDH directed therapy is important for patient care. Recently, mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) have been identified in the majority of lower-grade gliomas and a relatively small subset of GBMs. The genetic landscape of glioma is characterized by alterations in genes encoding epidermal growth factor receptor (EGFR), phosphate and tensin homolog deleted on chromosome 10 (PTEN), neurofibromatosis 1 (NF1), RAS, TP53, and cyclin dependent kinase inhibitor 2 (CDKN2A/B), among others, leading to cell proliferation and tumorigenesis. Recent advances in genetic engineering have enabled the production of mouse models of glioma that increasingly mimic the microenvironmental and genomic characteristics of human brain tumors. Over 80% of the genes in the mouse genome have direct human orthologs, thereby leading to adoption of the mouse as the dominant model organism for cancer biology and cancer therapy studies. In vivo cancer modeling provides numerous advantages over in vitro modeling. The intractability of these tumors highlights the need for clinical testing of new therapies that display robust activity in accurate mouse models of glioma. Despite advances in treatment, patients with GBMs have a median survival of 15 months and a 5-year survival rate of <10% with maximal resection and concomitant chemotherapy and radiation. Lower-grade gliomas tend to be slower growing and are less aggressive than higher grade gliomas, with the diagnosis of GBM conferring a dismal prognosis. Based on the histologic similarity of the tumor to glial cells, diffuse glioma is a broad term encompassing astrocytoma, oligodendroglioma, each of their anaplastic variants, and GBM. If convicted, Prine faces 10 years to life in prison.Diffuse gliomas are the most common primary tumor of the central nervous system (CNS) and are currently classified as lower-grade glioma (WHO grade II and III) or glioblastoma (GBM WHO grade IV) based on a combination of histologic and molecular features. The children were about that old, the detective replied. “That,” referred to, in Prine’s words “sexual interaction between family members.”ĭid the mom like to participate (in the incest and child rape) or just watch? “I enjoy both,” the detective replied, before asking Morton for his age preferences. “Are you into that?” Prine had written to the detective earlier. Earlier, Prine had explained in explicit detail exactly what he hoped to get out of the encounter: This case presents a world of smoke and mirrors.”Ī world of smoke and mirrors that nevertheless resolves into a pretty damning scene: Police busted Prine, carrying a pizza box, as he approached the supposed 32-year-old mother’s apartment on Nov. “It is not just officers who pose,” he told the court. ![]() Prine’s lawyer is taking the “Internet as fantasyland” defense, claiming his client was simply role-playing. hristmas”ĭetective James Morton, who posted the ad, was using the capital letters as a simple code: In pedophile circles, PTHC stands for “pre-teen hardcore.” The ad was an invitation, and Prine took Morton up on his offer. “P.hamily fun serious replies only bama won yes T.erday and kansas state lost don’t forget to H. The flurry of emails began with this message posted to the “Casual Encounters” section of Craigslist: Jurors heard opening statements yesterday in the case of Alan Preston Prine, 60, arrested last November after exchanging more than 200 emails with an undercover officer posing as a 32-year-old housewife offering up her two pre-teen kids for sex. A recent undercover sting in Mobile, Ala., provides a window into the secret world of coded language pedophiles use online. ![]()
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